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Introduction Messenger RNA (mRNA) has redefined what is possible in modern medicine. As a therapeutic platform, it enables rapid vaccine development, personalized cancer immunotherapy, and protein replacement strategies for rare diseases. However, behind every successful mRNA therapeutic lies a carefully engineered synthesis process. While clinical outcomes often dominate the conversation around mRNA therapeutics, the quality of mRNA synthesis ultimately determines translatio

Introduction Messenger RNA (mRNA), once a niche topic confined to molecular biology laboratories, has rapidly emerged as one of the most transformative technologies in modern medicine. While the COVID-19 pandemic brought mRNA vaccines into the global spotlight, their success was not an overnight miracle—it was the culmination of decades of foundational research, engineering breakthroughs, and persistent efforts to overcome the inherent fragility of RNA. Today, mRNA therapeuti

Introduction: The Delivery Problem in Nucleic Acid Therapeutics Nucleic acid therapeutics—such as mRNA vaccines, siRNA drugs, and CRISPR-based gene editors—have transformed modern medicine. However, the clinical success of these modalities depends not only on the therapeutic payload itself, but critically on how efficiently and selectively it can be delivered in vivo . Lipid nanoparticles (LNPs) have emerged as the gold-standard platform for systemic nucleic acid delivery. By

Introduction Over the past decade, lipid nanoparticles (LNPs) have emerged as a cornerstone technology in nucleic acid drug delivery , enabling the clinical success of messenger RNA (mRNA), small interfering RNA (siRNA), and gene-editing modalities such as CRISPR-Cas9. Approved products like Onpattro® (patisiran) and the mRNA COVID-19 vaccines from Pfizer-BioNTech and Moderna have demonstrated that effective delivery—rather than payload design alone—is often the decisive fa

Job Interview Red Flags: Why “I Don’t Make Mistakes” Is a Major Warning Sign (Interview Red Flags – Series #1) Introduction Many job candidates believe that presenting themselves as flawless is the safest interview strategy. However, from a hiring manager’s perspective, statements like “I don’t really make mistakes” are among the most common job interview red flags . This article examines why this response raises concern during job interviews, how interviewers interpret this

Introduction: When “More Experiments” Is No Longer the Answer In modern scientific research and engineering development, the central challenge is no longer whether to run experiments, but how to extract maximum insight from limited time, resources, and experimental capacity . Across drug development, bioprocess optimization, materials science, and platform R&D, researchers routinely face systems governed by multiple interacting variables. Traditional one-factor-at-a-time (OFA

Introduction | AI in Pharmaceutical Drug Development The pharmaceutical industry is undergoing a profound shift as AI in pharmaceutical drug development and digital transformation reshape how modern medicines are discovered, tested, manufactured, and delivered. In Part I of this series, we explored the essential functions inside pharma companies. In Part II, we examined how drugs navigate the regulatory approval process, market access, and post-market surveillance. In this t

Exploring the Pharmaceutical Industry: An Overview of the Journey from Regulatory Approval to Market Access and Post-Market Surveillance. Introduction In Part I, we explored the key departments that drive the pharmaceutical industry — from R&D and CMC to clinical trials and business development. But even after a drug proves safe and effective in clinical trials, the journey is far from over. Before a treatment can reach patients, it must pass through one of the most complex p

The pharmaceutical industry is more than just lab coats and experiments — it’s a complex ecosystem where science, engineering, and business intersect. From R&D and manufacturing to clinical trials, regulatory affairs, and business development, each department plays a critical role in transforming a molecule into a life-changing medicine. Explore how these teams work together to bring innovation from the lab to the patient.

In Part 1 , we explored how to decode job descriptions and approach the application journey strategically. In Part 2 , we transformed those insights into a data-driven résumé that gets noticed. Now in Part 3 , we’ll take the next crucial step — turning interviews from high-pressure tests into strategic conversations . 1. Research Beyond the Basics Preparation isn’t just memorizing company facts. Ask deeper questions: What’s the company’s growth story? How does this role contr

How to Prepare an Effective Resume That Gets You Interview Invitations A resume is the most important document when it comes to finding a job. Previously, I shared about the Curriculum Vitae (CV) required for school applications. But what exactly are the differences between a resume and a CV ? And how can we prepare an attractive resume that increases our chances of getting an interview invitation from hiring managers? In this article, I’ll walk you through what a resume

Graduating soon and feeling unsure about your job search? This guide shares seven practical tips to help you clarify your goals, build a strong resume, leverage networking, and stay positive through the process. Perfect for biotech and science students preparing to enter the industry.

Original Text Do not exalt the worthy, and the people will not contend. Do not value rare treasures, and the people will not steal. Do not display what arouses desire, and the hearts of the people will not be disturbed. Therefore, the sage governs by: Emptying their minds, Filling their bellies, Weakening their ambitions, Strengthening their bones. Always keeping the people unknowing and without desire, So that the clever ones do not dare to act. Act through non-action (wu we

Tao Te Ching Chapter 2: Relativity｜Original Text & Core Ideas When everyone in the world knows beauty as beauty, then ugliness already exists. When everyone knows good as good, then not-good already exists. Being and non-being give birth to each other; Difficult and easy complete each other; Long and short contrast each other; High and low incline toward each other; Sound and tone harmonize with each other; Front and back follow each other. Therefore, the sage acts through no

A solitary figure in traditional attire gazes over misty mountains, capturing the serene essence of contemplation in a landscape inspired by classical Chinese ink wash. Accompanying calligraphy reflects philosophical wisdom. Introduction As I’ve grown older, read more, and entered the professional world, I’ve found myself drawn to books that I never would have picked up as a student in Taiwan. In recent years, I’ve written extensively about leadership development and team gro

The giant in biomedical engineering, Robert Langer Introduction As a former postdoctoral researcher in Professor Robert Langer’s MIT lab , it is both an honor and a pleasure to introduce my mentor and share my personal journey into one of the most creative and influential research environments in the world. Professor Robert Langer at MIT is not only a pioneer in biomedical engineering but also a scientist whose work has fundamentally reshaped modern medicine, drug delivery,

Introduction In the previous article, we explored self-awareness leadership and why understanding our emotions, values, strengths, and blind spots is the foundation of effective leadership. However, self-awareness does not end with reflection and feedback alone. To deepen personality awareness leadership , leaders must also understand their behavioral patterns —how they naturally think, decide, communicate, and interact with others. One practical way to do this is through pe

Leadership Series (Series 2): Self-Awareness — The Foundation of Effective Leadership Introduction In the previous article, we explored Everyday Leadership and why leadership is not defined by job titles but by influence. This second article focuses on the core skill that shapes every great leader: Self-awareness — understanding yourself before you lead others. Self-awareness helps you recognize your emotions, strengths, weaknesses, values, and blind spots. Without this foun

Everyday Leadership (Series 1): Build Leadership Skills to Accelerate Your Career Growth Leadership today is no longer defined by titles or authority. In modern workplaces—especially in science, biotech, academia, and technology— leadership is a behavior , shaped by how we communicate, collaborate, and influence others. This article begins my leadership series by introducing the powerful concept of Everyday Leadership , a framework that helps anyone build leadership skills an

What engineers can do in biomedical field? Lessons from MIT and Robert Langer Engineers are trained to solve problems using science, mathematics, and systematic thinking. In our daily lives, civil, chemical, electrical, and software engineers continuously improve infrastructure, technology, and productivity. But what can engineers do in medicine? The answer lies in biomedical engineering applications —a field that translates engineering principles into real-world medical solu