All Posts

Biologics CMC Regulatory Framework: Executive Summary If you only have three minutes, remember these five points: Biologics CMC is not a single regulation. It is a lifecycle framework connecting the product, manufacturing process, analytical methods, control strategy, and pharmaceutical quality system. ICH provides a shared scientific language. FDA and European authorities apply those principles through their own laws, submission pathways, and post-approval change procedures.

Many people are surprised when they first read one of the most famous lines in the Tao Te Ching: “Heaven and Earth are not benevolent; they treat all things as straw dogs.” At first glance, this passage sounds cold—even cruel. It may seem as if Lao Tzu is saying that nature is indifferent to life and that human beings have little value. However, Tao Te Ching Chapter 5 is actually one of the most misunderstood chapters in the entire book. Lao Tzu is not advocating cruelty. He

Original Text The Tao is like an empty vessel;
Though used, it is never filled.
It is profound, the source of all things.
It blunts sharpness, untangles knots, softens brilliance, and becomes one with the dust.
It seems hidden, yet it always exists.
I do not know whose child it is;
It appears to have existed before Heaven itself. Tao Te Ching Chapter 4: Plain Language Explanation and Core Message Tao Te Ching Chapter 4 reminds us that true strength does not come from possessi

Executive Summary If you only have three minutes to read this article, here are five key takeaways: Aging is increasingly viewed as a biological process that can potentially be modified, rather than an inevitable consequence of time. The discovery of the Yamanaka Factors revolutionized modern biology by demonstrating that cell identity is reversible, leading to the development of induced pluripotent stem cells (iPSCs). Today, the most exciting direction in aging research is P

Executive Summary If you only have three minutes to read this article, I hope you'll remember these six things first. The real challenge of Gene Therapy is not just finding the therapeutic gene, but how to safely and effectively deliver the gene into the right cells. AAV (Adeno-associated virus) is one of the most mature in vivo gene delivery platforms currently available. Researchers remove most of the virus's genes, retaining only the structures needed for delivery, and the

學士、碩士、博士不是越高越好，而是要看你想用學位換到什麼職涯選擇權。這篇用 2026 年職場現實、研究訓練、biotech 與跨領域案例，幫你判斷該直接工作、念碩士，還是投入博士。

Figure 1. Evolution from autologous to off-the-shelf cell therapy. Comparison of autologous and allogeneic cell therapy manufacturing workflows. Unlike patient-specific manufacturing, iPSC-derived allogeneic therapies leverage Master Cell Banks (MCBs), standardized manufacturing processes, and large-scale production to enable scalable, off-the-shelf regenerative medicine. Executive Summary Key Takeaways Induced pluripotent stem cells (iPSCs) have evolved from a stem cell tech

Figure 1. The Journey of Induced Pluripotent Stem Cells (iPSCs): From Somatic Cell Reprogramming to Regenerative Medicine. Adult somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs), expanded and banked, differentiated into specialized cell types, and applied in disease modeling, drug discovery, regenerative medicine, and cell therapy. This workflow highlights how iPSCs serve as a foundational platform technology connecting basic research with transla

Introduction: The Biggest Exam After Graduation Is Finding a Job For many students, graduation marks the beginning of a new chapter in life. However, beyond finishing a thesis or passing the final exam, one of the most stressful challenges is often finding a job. Many students experience the same questions when they first enter the job market: What kind of job is right for me? Is my resume strong enough? Why am I not hearing back after submitting applications? How should I pr

Executive Summary Pfizer has introduced a new platform called USTAT (Unified Sequential Template Amplification and Transcription). The platform uses Rolling Circle Amplification (RCA) to establish an mRNA manufacturing process that does not rely on traditional plasmid DNA. The time from DNA template generation to mRNA production can potentially be reduced to approximately two days. RNA quality approaches that of conventional plasmid DNA-based manufacturing, although challenge

Introduction: For the First Time, Treatment Is About More Than Controlling Blood Sugar For more than a century, the treatment of Type 1 Diabetes (T1D) has been relatively straightforward. If the body cannot produce insulin, we replace insulin. This approach has saved millions of lives since the discovery of insulin in 1921. However, if we look deeper, one important fact becomes apparent: We have never truly addressed the underlying disease. The problem is not simply a lack of

Introduction: Leadership Is Not Just About Managing Talent In previous articles in this Leadership Series, I discussed: Everyday Leadership Self-Awareness Personality and Leadership Golden Circle Leadership Communication Leadership Cross-Cultural Communication Leadership Styles and Influence As organizations grow, however, leaders often face a different challenge. The question is no longer: “How do we hire the smartest people?” Instead, it becomes: “How do we help different p

Introduction: Many People Think mRNA Has Already Succeeded — But It’s Just Getting Started Ask most people what mRNA is, and you’ll probably hear answers like: COVID-19 vaccines Moderna Pfizer The breakthrough technology of the pandemic And they wouldn’t be wrong. COVID-19 vaccines represent one of the most successful commercial applications of mRNA technology in history. However, if you ask scientists working in RNA therapeutics, gene therapy, or drug delivery, you may hear

Introduction: There Is No Best Leadership Style—Only the Most Appropriate One In the previous articles of this Leadership Series, I discussed: Everyday Leadership Self-Awareness Personality and Leadership Golden Circle Leadership Communication Leadership Cross-Cultural Communication As we begin leading teams, however, another important question often arises: What is the best leadership style? At first glance, this seems like a simple question. But after years of working in ac

Introduction: The Next Bottleneck in mRNA Therapeutics May Not Be RNA—It May Be the LNP Since the successful launch of COVID-19 mRNA vaccines, mRNA technology has rapidly expanded beyond infectious diseases into areas such as cancer immunotherapy, gene editing, protein replacement therapy, and regenerative medicine. Many scientists believe the next decade will be the golden age of RNA therapeutics. However, anyone who has worked in mRNA drug development quickly realizes a fun

Introduction: Most People Aren’t Afraid of Negotiation — They’re Afraid of Rejection During the job search process, the moment that makes many people the most anxious is often not the interview itself, but the final offer negotiation. Especially in many Asian cultures, we are taught from a young age to: Be cooperative Don’t ask for too much Be grateful just to have a job As a result, when many people receive an offer, their first instinct is not to think about their market va

Introduction: The Hardest Part Is Usually Not Language — It’s Culture In the previous article, I discussed communication leadership, including: emotional regulation psychological safety trust building the curse of knowledge However, once teams become more diverse, communication enters another level of complexity: cross-cultural communication Today, we live in an increasingly global environment. Especially in biotech, technology, and startup industries, it is common to work wi

Notion has a program for early-stage startups: 3 months of Notion Business free with a company email. Here's how to apply, and how to build a startup OS that actually works — with Plaud for meetings and Coursera for AI learning.

Introduction: The Core of Leadership Is Communication In previous articles in this Leadership Series, I discussed: Everyday Leadership Self-awareness Personality and leadership styles Golden Circle Leadership and starting with “Why” However, one of the most important factors that determines whether a leader can truly align and guide a team is communication. Many people think communication simply means “speaking clearly.” In reality, communication is much deeper than informati