Introduction: Many People Think mRNA Has Already Succeeded — But It’s Just Getting Started Ask most people what mRNA is, and you’ll probably hear answers like: COVID-19 vaccines Moderna Pfizer The breakthrough technology of the pandemic And they wouldn’t be wrong. COVID-19 vaccines represent one of the most successful commercial applications of mRNA technology in history. However, if you ask scientists working in RNA therapeutics, gene therapy, or drug delivery, you may hear

Introduction How Amino Acids Enhance LNP mRNA Delivery: A New Direction for mRNA Therapeutics Over the past few years, lipid nanoparticles (LNPs) have become the cornerstone of modern mRNA therapeutics. From COVID-19 mRNA vaccines to cancer immunotherapy, rare disease treatment, and gene editing, LNPs are now one of the most important delivery platforms for nucleic acid medicines. But anyone who has worked in drug delivery knows a frustrating reality: An LNP system that perfo