Introduction: Are We Missing the Most Important Piece? Over the past few years, mRNA therapeutics has rapidly expanded—from vaccines to cancer immunotherapy, gene editing, and protein replacement. But if you’ve actually worked in this space, you’ve probably had this intuition: Often, it’s not that your design isn’t good enough—it’s that delivery just doesn’t work. So we optimize: Codon usage Nucleoside modifications Cap and poly(A) tail LNP formulations All of these matter. B